Causes And Treatment Of Sepsis - 1573 Words

‘Sepsis’, a lame man might hear of this word and have no clue or whatsoever of what this is – but in the real world it’s not something to be happy about and has been a major issue in the medical field. Sepsis is a complex condition which doesn’t have a specific definition, diagnosis or treatment but one thing the medical practitioners are specific of is the origin. Sepsis is from a Greek word called â€Å"Sepo† which means â€Å"decay† idiomatically known as â€Å"Blood poisoning† (Steen C., 2009). The medical field defines it as â€Å"Systemic Inflammatory Response Syndrome (SIRS) resulting from the presence of pathogens or their toxins as in septicaemia that occurs during an infected state.† (Sepsis Alliance, 2014). It is caused by a systematized†¦show more content†¦The organisms involved are staphylococcus and pseudomonas sp. About 60% of patients are as a result of cell membrane of gram-negative bacteria and 40% of gram-positive bacteria attach to binding protein on exterior immune cells identified by â€Å"CD14† receptors (Dob et al. 2007). Perrin (2009) suggested that that the body react to sepsis in three different phases; â€Å"inflammation, thrombosis/coagulation and Fibrinolysis†. The inflammatory phase of sepsis white blood cells discharges â€Å"proinflammatory cytokines†, neutrophils and bacteria stimulates the â€Å"proinflammatory cytokines† in severe sepsis however damaging the endothelium stimulating the coagulation cascade. Thrombosis is produced as the coagulation cascade is being stimulated giving rise to â€Å"procoagulant state† and â€Å"endothelial damage†. The final phase; fibrinolysis is slowed resulting to an interruption between clot development and disintegration balance, the imbalance leads to systemic inflammation. Inflammatory Cascade is the throbbing, reddishness, swelling and loss of function in the body which is constantly under attack from aggressive organism but nevertheless has the power to fight such attacks (Steen C., 2009). This is a normal phenomenon because it helps protect the body from injury and endurance from infection and as time goes on the aggressive organism is weakened which makes the body stable and healthy. There are three stages